The Clinical Profile and ۱-Year Prognosis of Patients With Cerebral Venous Sinus Thrombosis: A Study in Qom Province, Iran

Background and Aim:Cerebral Venous sinus Thrombosis (CVST) is a rare cerebrovascular accident with a vatiety of clinical symptoms. As there is evidence of a higher rate of CVST in Iran, we aimed to investigate the frequency of CVST, its predisposing factors, and ۱-year prognosis in Qom Province, Iran. Materials and Methods:We performed a cross-sectional study from ۲۰۱۸ to ۲۰۲۰ in Beheshti Hospital, Qom City, Iran. We reviewed the clinical and para-clinical records of the patients by a checklist. Follow-up visits were performed at ۱۲ months to evaluate the CVST recurrence, the neurological status according to modified Ranking Score (mRS), and persistence of neurological complaints. Eventually, we used SPSS version ۲۲ to analyze the obtained data. Results: We identified ۵۷ cases of definite CVST, which accounted for ۲.۵% of all cerebrovascular accidents in this period. We revealed a higher incidence of CVST among the women (۶۸.۴%). The use of oral contraceptives, pregnancy, and postpartum status were considered the main risk factors (n=۳۲/۳۹). We also revealed evidence of inherited coagulopathy in ۱۴.۰۳% of our patients, mainly due to protein S deficiency (n=۵). The superior sagittal sinus was the main involved sinus (۶۸.۴۲%) associated with other sinus thromboses in ۲۲% of all cases. We also showed a significant short-term and long-term recovery of the disease with a mean mRS score of ۱.۲۲ at discharge and ۱.۱۲ at a ۱-year follow-up. Conclusion: Oral contraceptives and fasting could contribute to developing CVST. We also revealed a favorable outcome following urgent treatment.

کلیدواژه ها:

Prognosis ، Cerebrovascular Disorders ، Cerebral Venous Sinus Thrombosis (CVST) ، Venous thrombosis ، Cerebral venous thrombosis