The Number of Sentinel Lymph Nodes Could be Optimized by Adjusting the Injection Dose
محل انتشار: فصلنامه سرطان پستان، دوره: 8، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 94
فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ARCHB-8-1_008
تاریخ نمایه سازی: 9 آبان 1401
چکیده مقاله:
Background: The optimal number of sentinel lymph nodes (SLNs) to beremoved is controversial based on the false negative rate and prognosis. Weinvestigated factors related to the number of SLNs and the possibility ofoptimizing the number of SLNs.Methods: We retrospectively reviewed ۱۶۷ cases in which ۰.۳ or ۰.۵ ml offerucarbotran was sub-dermally injected without massage from July ۲۰۱۶ toNovember ۲۰۱۸. Sentinel lymph node biopsy (SNB) was conducted using bothradioisotope (RI) and superparamagnetic iron oxide (SPIO). The removed nodeswith a value of ≥۰.۵ μT on a magnetometer were considered to be SLNs (SPIOnodes). The total SPIO node count in each case was calculated.Results: There was a significant correlation between the number of SPIOnodes and total count of SPIO nodes (rs=۰.۸۲۱, p<۰.۰۰۰۱). With RI and SPIOmethods, the average number of removed nodes in the age≥۷۵ years and BMI≥۲۵subgroups was significantly lower than that in the age<۷۵ years and BMI<۲۵subgroups. The number of SPIO nodes was significantly influenced by the injecteddose. The average number of SPIO nodes in the age ≥۷۵ years and BMI≥۲۵subgroups after injection of ۰.۵ ml was almost the same as that of the age <۷۵ yearsand BMI<۲۵ subgroups after injection of ۰.۳ ml.Conclusion: Obesity and old age seemed to be associated with slow lymphaticflow; however, increasing the dose increased the number of SPIO nodes. Thus,optimization of the number of SLNs seems possible.
کلیدواژه ها:
Sentinel node biopsy ، superparamagnetic iron oxide nanoparticles (SPIO) ، neodymium magnet ، magnetometer
نویسندگان
Masujiro Makita
Department of Surgery, Breast Surgery Division, Nippon Medical School Musashikosugi Hospital, Kanagawa, Japan
Eriko Manabe
Department of Surgery, Breast Surgery Division, Nippon Medical School Musashikosugi Hospital, Kanagawa, Japan
Michiko Sato
Department of Surgery, Breast Surgery Division, Nippon Medical School Musashikosugi Hospital, Kanagawa, Japan
Hiroyuki Takei
Department of Breast Oncology, Nippon Medical School Hospital, Tokyo, Japan