Antibacterial Activity of Methanolic Extract of Pistaciaatlantica Fruits using Disk Diffusion Method for the Treatment ofUrinary Tract Infections

Background and Aim : Nowadays, incidence of antibiotic-resistance among pathogenic bacteriahas increased due to indiscriminate use of antimicrobial drugs for treatment of diseases, especiallyurinary tract infections. Medicinal plants are also of great importance as antibacterial agents.Therefore, the aim of this study was to determine the antibacterial effect of methanolic extract ofPistacia atlantica fruits from Alborz province using disk diffusion method.Methods : Methanolic extract of Pistacia atlantica fruits was prepared by the Microwave- AssistedExtraction (MAE) method. Effect of different concentrations of the extract on Escherichia coli(PTCC ۱۳۹۹) and Staphylococcus saprophyticus (PTCC ۱۴۴۰) was evaluated using the diskdiffusion method by measuring diameter of growth inhibition zone. Gentamicin and propyleneglycol were used as positive and negative control, respectively.Results : The methanolic extract of Pistacia atlantica fruits had favorable inhibitory effect on thegrowth of Escherichia coli and Staphylococcus saprophyticus.Conclusion : The methanolic extract of Pistacia atlantica fruits has good inhibitory effect on thegrowth of Escherichia coli and Staphylococcus saprophyticus which confirms the traditional useof this plant for the treatment of urinary tract infections.

کلیدواژه ها:

Pistacia atlantica ، Staphylococcus saprophyticus ، Disk Diffusion ، Urinary TractInfections.