Therapeutic potential of fecal microbiota transplantation insystemic lupus erythematosus

Background and Aim : Systemic Lupus Erythematosus (SLE) is one of the chronic andautoimmune diseases that can involve and damage different body organs, including kidneys,bones, and skin. The prevalence of this disease in women is ten times more common than in men,and due to the high treatment costs and the problems it causes in daily life, it has become a severeproblem for patients. Fecal microbiota transplantation (FMT) is one of the new, efficient, andavailable treatment options for this disease. In this method, the balanced bacterial population of ahealthy person's intestine is screened during a process and transferred to the patient. A balancedmicrobial flora is one of the primary axes in body health, and this microbiota in people with SLEis out of balance and provides the basis for the development of subsequent disorders for the patientso that the FMT method can return the necessary balance to the patient's intestine and help to treatSLE faster.Methods : This article is a review, and its documents were collected by searching the keywords"systemic lupus erythematosus," "fecal microbiota transplantation," and "treatment" in PubMedand Scopus databases. From the ۲۲ articles searched between ۲۰۱۸ and ۲۰۲۲, we studied eightpapers with the most relevant topic and extracted their results.Results : Some studies showed that the FMT method increases the effectiveness of glucocorticoiddrugs in treating SLE and helps reduce the side effects of these drugs. FMT is also effective inregulating the balance of intestinal microbial flora and ultimately controlling SLE by increasingthe ratio of Firmicutes to Bacteroides and beneficial bacteria such as Ruminococcaceae andBifidobacterium (from bacteria that produce short-chain fatty acids beneficial for bodymetabolism). A study found that FMT not only can increase the diversity of the gut microbiomeof patients with SLE, like a healthy microbiota but also can change the function of the populationof these bacteria from pro-inflammatory to anti-inflammatory.Conclusion : According to the above findings, we can explain that fecal microbiota transplantationis a safe, effective, and efficient method for treating many metabolic diseases, including systemiclupus erythematosus, and helps to restore the balance of the body's microbial flora and reduce thecomplications of the disease.

کلیدواژه ها:

systemic lupus erythematosus ، fecal microbiota transplantation ، FMT ، SLE