Comparative study of antifungal effect of different activeherbal compounds

Background and Aim : The use of medicinal plants as antifungal agents in the diagnosis,prevention, and treatment of disease has a long history. Candida spp. is part of the naturalmicroflora of the human body and is the most common cause of fungal infections worldwide.Although Candida species are part of the normal flora of the skin and mucous membranes, theycan cause a wide range of infections, especially in people with immunodeficiency. Due to theincrease of resistant species to antifungal drugs and the side effects observed with the use ofchemical drugs, therapeutic agents derived from plants have been introduced as suitablealternatives against microbial pathogens. This study aims to investigate the antifungal activity ofthree plant-derived agents, including tannic acid, hesperidin, and piperine, and to compare theirability to reduce the growth of Candida albicans.Methods : The standard strain of Candida albicans fungus was cultured, and then the minimuminhibitory concentration (MIC) for each of the effective plant compounds was investigated by thebroth microdilution method.Results : The results showed that the fungus could not grow in the case of tannic acid and piperineat all tested concentrations, but the MIC in the presence of hesperidin was measured at ۳۱.۲۵ μg/ml.Conclusion : According to the results of this study, all three substances have outstandingantifungal potential and can be proposed as alternatives to chemical drugs

کلیدواژه ها:

Tannic acid ، Hesperidin ، Piperine ، Candida albicans ، Minimum inhibitoryconcentration.