Klebsiella pneumoniae vaccines: A systematic review

Background and Aim : The treatment of Klebsiella pneumonia, a common cause of hospitaland/or community-acquired infections, is faced with significant challenges demanding thedevelopment of prevention strategies including vaccination. However, no approved and globallyavailable vaccine exists, yet. Here, we systematically reviewed all published data on K.pneumoniae vaccines in both humans and animal models.Methods : Without time restrictions, three electronic databases including PubMed, Scopus, andWeb of Science were searched using appropriate keywords to retrieve published studies. Thestudies were screened and the data of those that matched our inclusion criteria were collected andanalyzed.Results : Totally, ۲۰۷۷ records were retrieved; of which ۳۸ studies were included for qualitativeanalysis (۳۵ studies were done on animal models and three studies were done on human samples).The most frequently used animal model was BALB/c mice. Proteins, polysaccharides, and theircombinations were the most vaccine candidates used. The amount of antigen, the route used forimmunization, and the challenge strategy was varying in the studies and were chosen based onseveral factors such as the animal model, the type of antigen, and the schedule of immunization.Almost all studies claimed that their vaccine was effective/protective, indicated by increasingsurvival rate, reducing organ bacterial load, and eliciting protective antibody and/or cytokineresponsesConclusion : Altogether, the information presented here will assist researchers to have a betterlook at the K. pneumoniae vaccine candidates and to take more effective steps in the future.

کلیدواژه ها:

Klebsiella pneumoniae ، Systematic review ، Vaccine