Prevalence and profile of antibiotic susceptibility of variousbacteria isolated from burn patients with ventilator-associatedpneumonia (VAP): A cross-sectional study in North of Iran

Background and Aim : Ventilator-associated pneumonia (VAP) is one of the most importantnosocomial infections, especially in intensive care unit (ICU) patients, which can increasemortality and treatment costs. Therefore, the present study identifies the etiological factors of VAPand patterns of antimicrobial resistance of these microorganisms in burn patients admitted to aburn hospital in northern Iran.Methods : This study was performed on burn patients admitted to the hospital from March ۲۰۱۷to March ۲۰۲۰. Patients ' files extracted information about age, sex, underlying diseases, length ofhospital stay, outcome, cause of the burn, and antibiotic resistance pattern. The results wereanalyzed by SPSS software version ۲۴.Results : Out of ۲۹ patients, ۲۲ (۷۵.۹%) were male patients. The mean age of patients was ۱۵.۹۶± ۴۱.۲۱ years. Pseudomonas aeruginosa (۴۸.۳%) and Klebsiella pneumonia (۱۷.۲%) were the mostcommon microorganisms causing pneumonia. Other microorganisms identified includedEscherichia coli (۱۰.۳%), Staphylococcus coagulase-negative (۶.۹%), and unknown (۱۷.۲%).There was no significant relationship between the type of pneumonia-causing microorganismswith sex, age group, burn percentage, underlying diseases, burn cause, and treatment outcome (P<۰.۰۵). Also, the highest resistance of the isolates was observed against the antibiotics ofofloxacin, ampicillin, tetracycline, clofazimine, vancomycin, cephalexin, cefixime, and cefoxitin.Amikacin (۵۲.۹%) and tobramycin (۴۱.۷%) were the most effective antibiotics.Conclusion : Since the statistical relationship between patients' gender, age group of patients,percentage of burns, underlying diseases, types of burn mechanisms, and therapeutic outcome ofthe disease was not seen with the type of microorganisms involved, it can be concluded that theenvironmental flora is more than the mentioned variables are related to the type of microorganismcausing pneumonia.

کلیدواژه ها:

pathogenic pattern ، ventilator-associated pneumonia ، burns