In silico study of association of has-mir-۵۶۹۸ with COVID-۱۹ severity in diabetics

Backgrounds: Coronavirus disease (COVID-۱۹) is an infectious disease caused by the newlydiscovered coronavirus. Increased severity of COVID-۱۹ has been observed in patients withdiabetes mellitus. This study aims to identify common genes in a comparison between twopathways, diabetic cardiomyopathy and coronavirus disease, and find an important regulator.MicroRNA (miRNA) is a powerful regulator of gene expression. Almost all the proteins in thepathways are controlled by specific miRNAs.Materials and Methods: In this study, I predicted by use of miRbase, miRWalk, NCBI, David,KEGG.Results: In the study, ۲۲ common genes with high-expression were found that are involved indiabetes and COVID-۱۹. The expression of these genes is regulated by various factors, such asmiRNAs. By using bioinformatics methods, I found has-mir-۵۶۹۸ targets ۱۱ of ۲۲ commongenes: mapk۱۰, mapk۱۱, mapk۱۲, mapk۱۳, mapk۱۴, mapk۸, nfkb۱, pik۳ca, pik۳r۱, pik۳r۲,pik۳r۳, prkcb.Conclusion: These ۱۱ genes are involved in the pathway of coronavirus disease, in cytokineinflammation and the cytokine storm that cause disease severity. They are also involved inphagocytosis. On the other hand, the same genes are involved in the pathway of diabetes, infibrosis, and in cytokine inflammation which predisposes diabetics to asthma and pulmonaryfibrosis. Thus, high expression of these genes in diabetes paves the way for COVID-۱۹ andcytokine storm. hsa-mir-۵۶۹۸ expression is expected to be low in the patients. It is suggested thatthe expression of these genes be reduced by increasing the expression of has-mir-۵۶۹۸ indiabetic patients infected with the coronavirus.

کلیدواژه ها:

Has-mir-۵۶۹۸ ، COVID-۱۹ ، Diabetes ، Inflammation ، Fibrosis