Thiazolium ring impregnated on silica gel: An insoluble catalyst for the preparationof γ-ketoesters

This work reports simple, highly efficient protocol for the preparation of γ-ketoesters. The thiazoliumring-impregnated on silica gel was prepared by the reaction between silica chloride and ۴-methyl-۵- (۲-hydroxymethyl) thiazole and then methylation of the thiazole ring by methyl iodide . Using this catalyst and inthe presence of a tertiary amine, γ-ketoesters were prepared from aldehydes and α,β-unsaturated esters withgood efficiency.

کلیدواژه ها:

Catalyst ، Thiazolium ، Silica chloride ، Aldehydes ، γ-Ketoesters ، α ، β-Unsaturated esters