The evaluation of responsiveness of pediatric epilepsy to low dose methylprednisolone pule

Introduction: Seizure is a transient occurance of signs and/or symptoms resulting from abnormal excessive or synchronous neural activity in brain. Epilepsy is a disorder of thebrain characterized by an enduring predisposition to generate seizures and by the neurobiologic, cognitive, psychological, and social consequences of this condition.Weaimed to assess the effect of low dose intravenous pulse of methyl prednisolone on pediatric epilepsy specially refractory type in children. Methods: In this case series, children with refractory seizure aged ۱ month- ۱۵ years referred to ۱۷ shahrivar hospital evaluate during ۳ years. ۳ pulses of ۱۵ mg/kg/ day intravenous methyl prednisolone in ۳ consecutive days followed by a weaning dose of ۱mg/kg/day oral prednisolone for ۱week were added concomitantly with patients’ stable dosage of routine treatment. Each child was followed up for ۶ months and the response for treatment was assessed. Results: Twenty children entered in this study consisting of ۸ girls (۴۰%) and ۱۲ boys (۶۰%). The mean age was ۶.۴۵±۳.۴۵ years. ۷۵% response by administering intravenous methyl prednisolone was mentioned. Symptomatic cause of refractory epilepsy was noted in ۱۱ (۵۵%) patients. The seizures were generalized tonic clonic in ۶ (۳۰%) patients. Conclusion: Although, previous investigations noted high doses of methyl prednisolone as efficient for treatment of pediatric epilepsy, according to our results , it seems that administering low dose intravenous methyl prednisolone in combination with other drugs can be an appropriate method with less complications.

کلیدواژه ها:

Child ، Steroid ، Refractory Seizure.