Comparison of local and systemic ciprofloxacin ototoxicity in thetreatment of chronic media otitis

Introduction:Chronic media otitis is a common cause of reference to ear, nose and throat clinics patients and its treatment is one of the health problems among ENT specialists. Ciprofloxacin drop is fluoroquinolone drug class that because of good treatment effect is now widely used in the treatment of chronic media otitis. Due to the widespread use, it seems enough research on the human population has not been taken to ensure its non-toxicity in the inner ear, therefore comparison of local ciprofloxacin ototoxicity with systemic in chronic media otitis is investigated in this study.Materials and methods:This study was conducted as a randomized clinical trial. Prospective methods were considered and the number of samples in the study group was ۴۰ patients that were treated with ciprofloxacin drops. In the control group ۳۲ patients with chronic media otitis who were treated with ciprofloxacin tablets. The collected data were analyzed using spss software.Results:Statistical indicators of different frequencies in air conduction (AC) in both groups showed improvement in hearing thresholds at frequencies of ۲۵۰, ۸۰۰۰, ۱۰۰۰ in air guiding for the group receiving drops compared to the group receiving tablet was significant. Statistical indicators in different frequencies of bone conduction in the two treated groups based on these indicators there was significant difference in the two groups receiving tablets and drops only at a frequency of ۴۰۰۰Hz that drop impact improves hearing threshold and in contrast in the group receiving tablet hearing loss was seen in the frequency of ۴۰۰۰.Discussion:Topical ciprofloxacin is an antibiotic used in the treatment of refractory chronic otitis that dregs such as pseudomonas aerogenusa and staphylococcus resistant to methicillin are responsible for it, are safe and uncomplicated ototoxic drugs that the usual doses prescribed have not harmful effects on hearing hairy cells.

کلیدواژه ها:

ciprofloxacin ototoxicity ، chronic media otitis