Comparison of different intensities of exercise on IP-10 gene expression in the male adult rats

One of the controversial topics that have attracted the attention of experts is the effects of different methods and intensities of exercise on the immune system. Interferon gamma-induced protein 10 (IP-10) is a small cytokine involved in the chemical uptake of certain immune system factors such as monocytes/ macrophages and T cells. The aim of this study was to investigate the effect of different intensities of interval training on IP-10 gene expression in adult male rats.In this study, twenty-four rats were divided into three groups: (1) High-intensity Training, (2) Low-intensity Training, and (3) Control groups. Training groups trained for 8 weeks and 5 days a week. The HIT group exercise program consists of running on a treadmill with five alternatives (8 minutes with 85-90% VO2max intensity and 2 minutes 50 60% VO2max intensity) and the LIT group exercise program is included five alternatives (8 minutes with 55-60% VO2max intensity and 2 minutes 45-50% VO2max intensity), that did a specific hour of the day and at the same time, the control group had no exercise. The expression of the IP-10 gene was measured in the soleus muscle. The data were analyzed by one-way ANOVA and Tukey post hoc test and statistical differences were considered significant at P<0.05.The results of this study showed that the expression levels of the IP-10 gene in the HIT group were significantly higher than the control group (P = 0.01, P = 0.04), while the levels of the IP-10 gene in the LIT groups were not significantly different than the control group (P = 0.2, P = 0.1). According to the results of the present study, it seems that High-intensity exercise can be more effective than low intensity in increasing immunity, which is dependent on IP-10 levels.

کلیدواژه های Comparison of different intensities of exercise on IP-10 gene expression in the male adult rats:

Interferon gamma-induced protein 10 ، High-intensity Training ، Low-intensity Training ، male adult rat