The effect of lycopene on serum level of cardiac biomarkers in patients undergoing elective percutaneous coronary intervention: A randomized controlled clinical trial

BACKGROUND: Myocardial ischemia may recur in a significant subset of patients following percutaneous coronary intervention (PCI). Lycopene, a carotenoid with antioxidant activity, has evidence for beneficial effects on cardiovascular system. In the present study, we aimed to evaluate the possible preventive effect of lycopene against post-PCI myocardial damage by detection of cardiac biomarkers of ischemia.METHODS: A total of ۴۵ patients who planned to undergo elective PCI were randomly assigned to two groups to receive either lycopene (۳۰ mg ۱۲ hours before PCI as well as ۱۵ mg just before and ۸ hours after PCI) along with standard treatment (n = ۲۳) or only standard treatment (n = ۲۲). Standard treatment included aspirin, a statin, and a beta-blocker. The serum levels of creatine kinase-MB (CK-MB), troponin I, and high sensitivity C-reactive protein (hs-CRP) were measured ۱۲ hours before and ۱۲ hours after the procedure and were compared between the two groups.RESULTS: The use of lycopene significantly prevented the increase of CK-MB following PCI compared to control (P = ۰.۰۴۸). However, it had not any significant effect on serum levels of troponin I (TnI) (P = ۰.۱۷۶) and hs-CRP (P = ۰.۱۸۶) compared to control.CONCLUSION: Lycopene can prevent the increase of CK-MB following PCI. Therefore, it has the potential for prevention of post-PCI cardiovascular events. However, more studies are needed to confirm such an effect.

کلیدواژه ها:

Lycopene ، Troponin I ، Creatine Kinase-MB ، High Sensitivity C-reactive Protein ، Percutaneous Coronary Intervention