Effect of Eight Weeks of Resistance Training on PAX۷ and MyoD in Fast and Slow-Twitch Skeletal Muscles of Old Rats
محل انتشار: فصلنامه پزشکی هرمزگان، دوره: 25، شماره: 2
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 128
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شناسه ملی سند علمی:
JR_HMJ-25-2_007
تاریخ نمایه سازی: 30 مرداد 1401
چکیده مقاله:
Background: Box ۷ protein (PAX۷) and myogenic differentiation (MyoD) proteins are the essential proteins to regulate the satellite cell and muscle hypertrophy.Objectives: We aimed to investigate the effect of resistance training (RT) on PAX۷ and MyoD in soleus and extensor digitorum longus (EDL) muscles of old rats.Methods: In this experimental study, ۱۲ old female rats were randomly divided into two groups including RT and control groups. The RT program was three days a week for eight weeks, in which the rats climbed a one-meter vertical ladder with ۲۶ steps. The carried weights varied from ۵۰% of body weight in the first week to ۱۰۰% of body weight in the ۸th week. Kolmogorov- Smirnov test and independent sample t test was used for statistical analysis (P≤۰.۰۵).Results: MyoD protein in RT group significantly increased in soleus and EDL muscles compared with the control group (P = ۰.۰۰۱). Also, Pax۷ significantly increased in the soleus muscle in the RT group compared with control group (P = ۰.۰۰۲); nevertheless, there was no significant difference in Pax۷ protein in the EDL muscle between the RT and control groups (P = ۰.۱۰).Conclusion: RT can lead to proliferation and renewal of satellite cells in the soleus and EDL muscles by increasing PAX۷ and MyoD proteins.
کلیدواژه ها:
نویسندگان
Hossein Esmaeili
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Javad Nemati
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Farhad Daryanoosh
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran
Mohammad Hemmatinafar
Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran