AAK۱ circular regulates neuronal development by interacting with miR-۱۳۲, miR-۱۴۶a and miR۴۸۴

Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterized by communication and social interaction impairment. Circular RNAs were discovered to be extremely enriched in the mammalian brain, to be highly conserved in sequence, and it has been demonstrated that circular RNAs deregulate in ASD postmortem brains. In the present study, we attempted to answer the question of which circular RNA can inhibit pathogenic ASD miRNAs. ASD miRNAs were downloaded from HMDD and three including miR-۱۳۲, miR-۱۴۶a and miR۴۸۴ were selected. Their pathogenic role in ASD was determined experimentally. miRNAs gene targets predicted by miRDB and AAK۱ were obtained as a common target gene. circular RNA origin from exons so, miRNAs could bind to their circular gene targets. AAK۱ circular RNAs downloaded from circAtlas ۲.۰ and results blasted by NCBI BLAST. Finally, ۱۰ circular RNA was obtained for AAK۱.

کلیدواژه ها:

Autism ، circular RNA ، AAK۱ ، miR-۱۳۲ ، miR-۱۴۶a and miR۴۸۴