Differential Expression of miRNAs in HPV-Based Carcinogenesis of Cervix; Oncogenic miRNAs Versus Tumor Suppressor miRNAs

Human papillomavirus is one of the leading causes of urogenital cancers especially cervicalcancer and plays a significant role in cancer related death in the developing countries. Persistedinfection with high-risk types of HPV is considered as main cause of cervical carcinogenesis.Micro-RNAs are a group of small non-coding RNAs of ۱۸-۲۵ nucleotides capable of posttranscriptionalgene silencing and participated in the fundamental cellular and molecularmechanism, e.g. cell proliferation, differentiation, migration, cardiovascular andneurodegenerative diseases, and development and progression of cancer.Recently, studies have focused on the role of miRNAs in tumorigenesis processes and found thatmiRNAs could play a dual role. Oncogenic miRNAs that are upregulated during tumorigenesiscan promote cell proliferation and dedifferentiation, while inhibiting apoptosis. On the otherhand, tumor suppressor miRNAs, downregulated during tumor development. This study aimed toreview studies that have investigated differential expression of miRNAs in HPV-based cervicalcancer and evaluate the role of miRNAs in outcomes of HPV infection.A group of miRNAs are found to be upregulated in cervical cancer cell lines and tissues, and theother group, downregulated. In conclusion, the data highlighted the expression and function offour extensively studied miRNAs. Over-expression of miR-۲۱ and miR-۹a introduced them asoncomiRs, while downregulation of miR-۳۴a and miR-۲۹ confirmed their protective role astumor suppressor miRNAs in cervical cancer development and progression. Altogether,differential expression of miRNAs can be helpful in determination of molecular diagnostic andprognostic markers. Also, they can be considered as good targets for therapy purposes

کلیدواژه ها:

Cervical Cancer ، Human Papillomavirus ، Oncogenic miRNA ، Tumor SuppressormiRNA ، Carcinogenesis .