بررسی تاثیر تجویز زنجبیل بر میزان بهبودی سندرم تخمدان پلی کیستیک

Background and objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. The pathophysiology of PCOS is complex, therefore, in the present study, we investigated ginger extract as an antioxidant in PCOS mice.Materials and Methods: In this experimental study, PCO model was developed in adult female mice during ۸ weeks. The ۱۵ mice were divided in three groups include control, PCO model (using estradiol valorite or EV at ۴۰ mg/kg), volatile oil of ginger (oral administration ۰.۵ g/kg body weight dose). After mice sacrifing, their ovarian tissue was removed and histological and morphometric studies were performed. After tissue lysis, total antioxidant capacity was measured by FRAP method and oxidative stress was measured by flow cytometry.Results: The results of tissue sections showed that EV administration caused cyst formation in the study groups. Cyst formation and the percentage of preantral and antral follicles in the group that received ginger were significantly lower (P ≤ ۰.۰۱) than EV group. In the group that received a combination antioxidants (ginger), the level of oxidative stress and total antioxidant capacity were the lowest and highest, respectively, compared to the other groups.Conclusion: The results showed that administration of ginger in PCO mice, in addition to reducing the amount of oxidative stress by increasing the antioxidant properties, but also by reducing the number of cysts and improved the symptoms of this syndrome.

کلیدواژه ها:

Polycystic ovary ، ginger ، antioxidant