The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 191

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شناسه ملی سند علمی:

JR_CMBR-2-1_002

تاریخ نمایه سازی: 29 خرداد 1401

چکیده مقاله:

The applications of nanoparticles in various practical fields, owing to their unique properties compared with bulk materials, have been occupying the minds of scientists for several decades. In this regard, a combination of pharmacology and nanotechnology has contributed to producing newer effective anticancer and antimicrobial agents to inactivate resistant cancer cells and microorganisms, specifically multidrug-resistant ones. The physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. Therefore, the main objective of this review is to report an overview of the recent signs of progress in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.

نویسندگان

Mehran Alavi

Department of Biological Sciences, Faculty of Science, University of Kurdistan, Sanandaj, Iran

Mahendra Rai

Nanobiotechnology Laboratory, Department of Biotechnology, SGB Amravati University, Amravati-۴۴۴ ۶۰۲, Maharashtra, India

Fleming Martinez

Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, South America, Colombia

Danial Kahrizi

Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

Haroon Khan

Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber-Pakhtunkhwa, Pakistan

Irwin Rose Alencar de Menezes

Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry; Regional University of Cariri; Rua Coronel Antônio Luis ۱۱۶۱, Pimenta, CEP ۶۳۱۰۵-۰۰۰, Crato, Ceará, Brazil

Henrique Douglas Melo Coutinho

Laboratory of Microbiology and Molecular Biology; Department of Biological Chemistry; Regional University of Cariri; Rua Coronel Antônio Luis ۱۱۶۱, Pimenta, CEP ۶۳۱۰۵-۰۰۰, Crato, Ceará, Brazil

José Costa

Research Laboratory of Natural Products, Department of Biological Chemistry, Regional University of Cariri, Crato, CE ۶۳۱۰۵-۰۰۰, Brazil

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