Antidiabetic, Antioxidant and Hypolipidemic potentials of Sterculia Setigera Methanol Stem Bark Extract in Alloxan-Induced Diabetic Rats

Background: Sterculia setigera is one of the medicinal plants used traditionally to treat various diseases with the insertion of diabetes. Diabetes mellitus is a prolonged metabolic disorder recognized as a hyperglycemia. The present study is aimed at investigating the antidiabetic activity of the methanol stem bark extract of Sterculia setigera. Methods: LD۵۰ screening was evaluated using standard methods. The sub-chronic effect of Sterculia setigera methanol stem bark extract on body weight, antidiabetic, antioxidant, lipid profile and histopathology were evaluated in Alloxan-induced diabetic rats respectively. Result: Acute toxicity study of methanol stem bark extract of Sterculia setigera reveal no mortality in the animals at the limit dose of ۵۰۰۰mg/kg during the ۱۴ days observation period. In the invivo study, alloxan was capable of inducing diabetic conditions as there was a significant increase (P<۰.۰۵) in the fasting blood glucose (FBG) of the entire induced groups compared to normal control. Groups treated with crude extract of Sterculia setigera (۱۰۰-۴۰۰mg/kg) and the standard drug (glibenclamide) showed a significant decrease (P<۰.۰۵) in FBg compared to diabetics control. There were significant reductions (P<۰.۰۵) in serum TC, TG, VLDL, LDL, CAT, SOD, GPx, Vit E, Vit A, and MDA against diabetic control. On the other hand, significant increments (P<۰.۰۵) in body weight and HDL were observed in the treated groups compared to diabetic control diabetic. Histopathological examination showed improvement in the regeneration of pancreatic β-cells islets. Conclusion: In conclusion, Sterculia setigera stem bark extract exhibit hypoglycaemic, hypolipidemic, and antioxidant effects justifying its ethnomedicinal use for the treatment of diabetes.

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Keywords: Antidiabetic ، alloxan ، Sterculia setigera ، hypolipidemic ، Antioxidant ، Glibenclamide