Incorporation of microalgae aminoacid extracts into gelatin-pectincomposite solution, particles, film and fiber to improve antioxidantand anti-diabetic properties

This study evaluates the anti-diabetic and anti-oxidative potential of hydrolyzed extractsfrom three major micro algae Parachlorella kessleri, Haematococcus pluvialis andScenedesmus obliqus by using simulated in vitro gastrointestinal digestion. Thephytochemical analysis showed that hydrolyzed extracts are rich in active substancessuch as essential fatty acids, functional amino acids, monosaccharides and phenoliccompounds. This study showed that, algae extracts exhibited moderate anti-glucoseoxidation, anti-lipid peroxidation, anti-protein oxidation, and anti-protein glycation, alsowith a semi-strong capacity for anti-amylase and anti-glucosidase activity. These effectsmay be due to considerable potentials of these compounds in metal ions and freehydroxyl radicals scavenging, as well as competitive and mixed non-competitiveinhibition of α-amylase and α-glucosidase activities. Water: acetic acid solvent was usedto prepare gelatin-pectin composite nanoparticle, nanofiber, and film incorporated withthe aminoacid extracts. Low conductivity, low surface tension, negative zeta-potential,and nanoscale particle size was the main characteristics of the gelatin-pectin solutionincorporated with the aminoacid extracts. This character results in spherical andhomogenous particle generated. Also, a homogenous thin film with good morphologicalproperties produced. Because of their good anti-diabetic activities against lipid andprotein oxidation and carbohydrate-degrading enzymes, aminoacid extracts-incorporatedin gelatin-pectin nanofibers and films are strongly recommended as natural.nutraceuticals for diabetes management

کلیدواژه ها:

Microalgae ، Amino acid ، Anti-oxidative ، Anti-diabetes properties ، nano fiber and film