Correlation between Serum Levels of Calprotectin with Disease Activity in Rheumatoid Arthritis Patients

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 157

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شناسه ملی سند علمی:

JR_ZUMS-30-140_009

تاریخ نمایه سازی: 11 اردیبهشت 1401

چکیده مقاله:

Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease defined by chronic synovitis and progressive joint destruction. This study investigated calprotectin as a serological marker in the hope of establishing an adequate means of diagnosing RA and following up on patients. Materials and Methods: This cross-sectional study included ۳۲ RA patients who were referred to the rheumatology clinic of Baqiyatallah Hospital (Tehran, Iran) from ۲۰۱۹ to ۲۰۲۰. clinical examinations and requested laboratory tests was performed. The final visit was placed after a year with the same method as the initial visit. Disease activity was assessed by Disease Activity Score ۲۸ (DAS-۲۸) for ۲۸ joints which is assessable by ESR or CRP and data were analyzed by SPSS ۲۰ version. Results: Changes over time were significant in both (P=۰.۰۰ and P=۰.۰۰), and a significant relationship was found between the quantitative scores of the two forms of DAS-۲۸ (P<۰.۰۰۰). Calprotectin did not show any significant correlation with either form of the DAS-۲۸ quantitatively. Ahead of logistic regression analysis on the after one-year C-reactive protein based DAS-۲۸ data, patients with cured disease or low disease activity were combined into one group. Accordingly, calprotectin was able to predict RA activity level to some extent (P=۰.۰۶), though a more efficient prediction was achieved when erythrocyte sedimentation rate and calprotectin were applied together (P=۰.۰۳). Conclusion: ESR and calprotectin did not show good power in predicting disease activity individually but they could have significantly high prediction potency combined.

نویسندگان

Gholam Hossein Alishiri

Dept. of Rheumatology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

Ramezan Ali Ataee

Dept. of Medical Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

Mahsa Ramezanpour

Dept.of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

Danial Chaleshi

Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Ehsan Rahmanian

Dept.of Rheumatology, School of Hormozgan University of Medical Sciences, Bandar-e Abbas, Iran

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