Correlation between Serum Levels of Calprotectin with Disease Activity in Rheumatoid Arthritis Patients
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 157
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ZUMS-30-140_009
تاریخ نمایه سازی: 11 اردیبهشت 1401
چکیده مقاله:
Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease defined by chronic synovitis and progressive joint destruction. This study investigated calprotectin as a serological marker in the hope of establishing an adequate means of diagnosing RA and following up on patients.
Materials and Methods: This cross-sectional study included ۳۲ RA patients who were referred to the rheumatology clinic of Baqiyatallah Hospital (Tehran, Iran) from ۲۰۱۹ to ۲۰۲۰. clinical examinations and requested laboratory tests was performed. The final visit was placed after a year with the same method as the initial visit. Disease activity was assessed by Disease Activity Score ۲۸ (DAS-۲۸) for ۲۸ joints which is assessable by ESR or CRP and data were analyzed by SPSS ۲۰ version.
Results: Changes over time were significant in both (P=۰.۰۰ and P=۰.۰۰), and a significant relationship was found between the quantitative scores of the two forms of DAS-۲۸ (P<۰.۰۰۰). Calprotectin did not show any significant correlation with either form of the DAS-۲۸ quantitatively. Ahead of logistic regression analysis on the after one-year C-reactive protein based DAS-۲۸ data, patients with cured disease or low disease activity were combined into one group. Accordingly, calprotectin was able to predict RA activity level to some extent (P=۰.۰۶), though a more efficient prediction was achieved when erythrocyte sedimentation rate and calprotectin were applied together (P=۰.۰۳).
Conclusion: ESR and calprotectin did not show good power in predicting disease activity individually but they could have significantly high prediction potency combined.
کلیدواژه ها:
نویسندگان
Gholam Hossein Alishiri
Dept. of Rheumatology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Ramezan Ali Ataee
Dept. of Medical Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mahsa Ramezanpour
Dept.of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
Danial Chaleshi
Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Ehsan Rahmanian
Dept.of Rheumatology, School of Hormozgan University of Medical Sciences, Bandar-e Abbas, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :