Lipid- lowering Effects of Endurance Training and Cinnamon Extract in Streptozotocin- Induced Diabetic Rats

Introduction: Diabetes is a disease caused by a lack of insulin secretion or a decrease in tissue sensitivity to insulin. The aim of this study was to investigate the lipid-lowering effects of endurance training (ET) with cinnamon (C) extract in streptozotocin (STZ)-induced diabetic rats.Methods: Thirty-two diabetic rats were divided into four groups of ۸ rats, including ۱) cinnamon, ۲) training, ۳) training+cinnamon and ۴) sham groups. During four weeks, groups ۱ and ۳ received daily ۱۰۰ mg/kg C perennially, and groups ۲ and ۳ ran on treadmill five times per week for ۶۰ minutes each session at a speed of ۸ to ۱۶ m/min. Data were analyzed using paired sample t test and one way ANOVA and Tukey’s post-hoc tests (p≤۰.۰۵).Results: cinnamon, training and training+cinnamon significantly reduced TG, LDL and VLDL levels as well increased HDL (P=۰.۰۰۱) in compare with sham group, training+cinnamon significantly reduced Cho and VLDL (P=۰.۰۰۱) in compare with sham group; training+cinnamon had more effect on decrease of Cho (p=۰.۰۲) and LDL (p=۰.۰۰۲) as well as increase of HDL (P=۰.۰۰۴) rather than training. Also cinnamon (P=۰.۰۳) and training (P=۰.۰۴) significantly reduced VLDL in compare with sham group.Conclusions: Although training and cinnamon have lipid-lowering effect in diabetic rats, nevertheless it seems training simultaneously with cinnamon administration has better effect on improving lipid profile compare to training alone.

کلیدواژه ها:

Diabetes Mellitus ، Cinnamomum zeylanicum ، Lipids ، Exercise ، Endurance training