Preparation and characterization of zein nanoparticles as drug carriers

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 257

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شناسه ملی سند علمی:

SDNCONF06_006

تاریخ نمایه سازی: 2 بهمن 1400

چکیده مقاله:

Curcumin is a polyphenol with multiple biological activities, but it extremely poor water solubility severely limits its application. The aim of the present study was to design nanocomposite by using zein and bentonite for controlled release of curcumin under condition of PH = ۵, ۷.۴. Fourier transform infrared spectroscopy confirmed that curcumin bound to zein through hydrogen bonding. The in-vitro drug release was studied by using UV–Visible spectrophotometer at acidic environment (pH ۵.۰) and physiological pH (pH ۷.۴) and sustained release compared to the curcumin alone. It was found that curcumin drug is released much faster in pH ۵.۰ than in the pH ۷.۴.

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نویسندگان

Zahra Khakpourian

Department of Chemistry, Zagros institute of higher education , Kermanshah, Iran

Azita farrokhi

Department of Chemistry, Zagros institute of higher education , Kermanshah, Iran