Prognostic significance of BAG۳ expression in cancer progression: A Meta-analysis

Introduction: There is growing evidence for a constitutive over-expression of bcl-۲-associated athanogene (BAG)-۳ in several tumor types, accounting for cancer cell viability, tumorigenesis, and resistance to treatment. We aimed to explore the relationship of BAG۳ gene expression with prognosis and clinical parameters of cancer patients in a meta-analysis of the existing data. Methods: The electronic search was performed in PubMed, Scopus, Web of Science as well as Embase up to January of ۲۰۲۱. Regarding to the prognostic meta-analysis, specific hazard ratios (HRs), data related to tissue BAG۳ expression and survival outcome for each study were gathered. Pooled odds ratios (OR) were used to explore the relation of BAG۳ expression and clinicopathological factors in patients with cancer. Results: Fourteen studies comprising ۲۰۴۷ patients with ۱۱ different cancers were included in meta-analysis. The pooled odds ratio revealed an association between increased BAG۳ expression and poor clinicopathological factors, including cell differentiation (OR=۰.۲۵, ۹۵% confidence interval [CI]: ۰.۰۸–۰.۷۴), lymphatic invasion (OR=۲.۶, ۹۵% CI: ۱.۱-۵.۹) and clinical stage (OR=۳.۸, ۹۵% CI: ۲.۰۱–۷.۱۶). High levels of BAG۳ expression were predictive of an unfavorable overall survival in cancer patients (HR=۲.۵, ۹۵% CI: ۱.۵–۳.۲; P<۰.۰۰۱). Conclusion: The meta-analysis revealed that BAG۳ overexpression may predict a poor prognosis in cancer patients.

کلیدواژه ها:

CAIR-۱ ، Bis ، survival ، malignancy ، prognosis