Is Gabapentin Effective on Pain Management after Arthroscopic Anterior Cruciate Ligament Reconstruc tion? A Triple Blinded Randomized Controlled Trial

سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 203

فایل این مقاله در 5 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_TABO-1-1_004

تاریخ نمایه سازی: 26 دی 1400

چکیده مقاله:

Background: Acute pain is common after arthroscopic surgeries and it is one of the most important causes of patient dissatisfaction, admission time and increased morbidity . Gabapentin with anti-hyperalgesic effects can play a critical role in pre-emptive analgesia methods. The aim of this study was to assess the efficacy of gabapentin in pain management after surgery and the rate of drug consumption in patients who are candidate for anterior cruciate ligament (ACL) reconstruction arthroscopic surgery. Methods: In this randomized, triple blind clinical trial, ۱۱۴ patients who were candidate for arthroscopic ACL reconstruction were divided into two groups of gabapentin (G) and placebo (p), with ۵۷ patients in each group. The intervention group received gabapentin ۶۰۰ mg and a placebo was administered in control group. Patients received on-demand pethedine for pain management. The primary outcome was pain intensity according to the visual analogue scale (VAS) and the secondary outcome was the amount of opioid consumption and incidence of side effects (including: dizziness, sedation, nausea and vomiting) at ۶ and ۲۴ h visits. Results: The mean pain intensity in G group at both the ۶ and ۲۴ hour visits was significantly lower than the control group (Both p <۰.۰۰۰۱). Also, patients in the gabapentin group consumed less opioid at both visits in comparison to the placebo group (p <۰.۰۰۱, p =۰.۰۳۲). The incidence rate of sedation, dizziness, nausea and vomiting was similar in both groups. Conclusion: In arthroscopic ACL reconstruction, administering a preoperative single dose of ۶۰۰mg gabapentin may decrease both pain intensity and opioid consumption.

نویسندگان

Mohsen Mrdani Kivi

Department of Orthopedic Surgery Guilan Road Trauma Research Center, Guilan University of Medical, Sciences, Rasht, Iran.

Mohammad Karimi Mobarakeh

Department of Orthopedic Surgery Kerman University of Medical Sciences, Kerman, Iran.

Sohrab Keyhani

Orthopedic Research Center Guilan University of Medical Sciences, Rasht, Iran.

Keyvan Hashemi Motlagh

Orthopedic Research Center Guilan University of Medical Sciences, Rasht, Iran.

Khashayar sahab Ekhtiari

Orthopedic Research Center Guilan University of Medical Sciences, Rasht, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Spence D, Goff J, Mohan E, Bowen K, Osborne L, ...
  • Alentorn-Geli E, Lajara F, Samitier G, Cugat R. The transtibial ...
  • Dargel J, Schmidt-Wiethoff R, Fischer S, Mader K, Koebke J, ...
  • Bang SR, Yu SK, Kim TH. Can gabapentin help reduce ...
  • Weinbroum AA. Non-opioid IV adjuvants in the perioperative period: pharmacological ...
  • Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative ...
  • White PF. The role of non-opioid analgesic techniques in the ...
  • Elvir-Lazo OL, White PF. The role of multimodal analgesia in ...
  • Kehlet H, Dahl JB. The value of “multimodal” or “balanced ...
  • Al-Mujadi H, A-Refai AR, Katzarov MG, Dehrab NA, Batra YK, ...
  • Dahl JB, Mathiesen O, Moiniche S. ‘Protective premedication’: an option ...
  • Dauri M, Faria S, Gatti A, Celidonio L, Carpenedo R, ...
  • Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, ...
  • Hurley RW, Cohen SP, Williams KA, Rowlingson AJ, Wu CL. ...
  • Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, ...
  • Radhakrishnan M, Bithal PK, Chaturvedi A. Effect of preemptive gabapentin ...
  • Short J, Downey K, Bernstein P, Shah V, Carvalho JC. ...
  • Kinney MA, Mantilla CB, Carns PE, Passe MA, Brown MJ, ...
  • Paul JE, Nantha-Aree M, Buckley N, Cheng J, Thabane L, ...
  • Adam F, Menigaux C, Sessler DI, Chauvin M. A single ...
  • Menigaux C, Adam F, Guignard B, Sessler DI, Chauvin M. ...
  • Turan A, Karamanlioglu B, Memis D, Hamamcioglu MK, Tukenmez B, ...
  • Turan A, Kaya G, Karamanlioglu B, Pamukcu Z, Apfel CC. ...
  • Waikakul W. Combination of gabapentin and celecoxib for analgesia after ...
  • Gilron I. Gabapentin and pregabalin for chronic neuropathic and early ...
  • Ho KY, Gan TJ, Habib AS. Gabapentin and postoperative paina ...
  • Clarke H, Pereira S, Kennedy D, Gilron I, Katz J, ...
  • Clarke H, Pereira S, Kennedy D, Andrion J, Mitsakakis N, ...
  • Brogly N, Wattier JM, Andrieu G, Peres D, Robin E, ...
  • Menda F, Köner Ö, Sayın M, Ergenoğlu M, Küçükaksu S, ...
  • Sen H, Sizlan A, Yanarates O, Emirkadi H, Ozkan S, ...
  • Srivastava U, Kumar A, Saxena S, Mishra AR, Saraswat N, ...
  • Moore A, Costello J, Wieczorek P, Shah V, Taddio A, ...
  • نمایش کامل مراجع