Macr oscopic an d Micros copic Prot onation C onstants of Alanin e in Aque ous solutions of ۱-pro panol

The acidic macrosco pic and microscopic dissociation constants are among im portant ph ysico-chemical property of all amino acids, specially in ADM ET (absorpt ion, distribution, metabo lism, excretion, and toxicity) processes. In this way, potentiometry technique is very useful and well-established in curr ent determination of pharmaceutical or biological int erest. Whe n the compounds are sparingly soluble in water, the pKa dete rmination is commonly done in organic solvents or better in aqueous or ganic mixt ure. Alcohol-water mixtures are often used because they hav e a lower polarity than pure water, but keeping a similar environment.

کلیدواژه ها:

Potentiometry ، Ala nine ، ۱-Pro panol ، Mixed Solvent ، Micro and M acro Proton ation Constants.