Application of Multiw all Carbon Nanotu bes and Rutin as a Mediat or for Glutathione A nalysis

A new sensitive and selective electrochemical sensor was developed for electrocatalytic determination of glutathion e (GSH) in pharm aceutical and biological samples. A voltam metric study of GSH has been c arried out at the surface of carb on paste electrode modifie d with m ultiwall carbon nanot ubes in th e presence of rutin as a mediat or. The electroc hemical oxidation of GSH was i nvestigated by cyclic voltammetry, chrono amperomet ry and squa re wave v oltammetry (SWV) tec hniques. Under the o ptimized conditi ons, the pea k current w as linear t o GSH con centration over the con centration range of ۰.۳ to ۱۸۰ µmol L-۱ using SWV. The detection limit was ۰.۰۹ µmol L-۱. The proposed method was successfully applied to th e determin ation of GSH in the urine, ta blet and hemolysed erythrocyte sampl es.

کلیدواژه ها:

Multiwall carbon nanotubes ، Glutathio ne ، Rutin ، M odified ele ctrode