n-octanol/water partition coefficient and solubility measurements of propranolol and atenolol at different temperatures

Propranolol is a non-selective beta blocker mainly used in the treatment of hypertension. Atenolol is a drug belonging to the group of drugs used primarily in cardiovascular diseases. The information obtained from the partitioning behavior of drugs in simple hydrophobic/hydrophilic systems such as n-octanol/water system can be used for prediction of the drug partitioning behavior in realistic biological membranes. The partition coefficient between n-octanol and water is defined as the ratio of the equilibrium concentrations of the test chemical in n-octanol saturated with water and water saturated with n-octanol and expressed as the logarithm of partition coefficient. The NRTL and UNIQUAC activity coefficient models were used for correlating of the equilibrium drugs concentrations in the n-octanol and water phases. The influence of temperature on the solubility is also discussed [۱-۲].

کلیدواژه ها:

Propranolol ، Atenolol ، Partition coefficient ، Solubility ، Activity coefficient model