QS AR investigation on quinolizidinyl der ivatives i n Alzheimer’s disease

Alzheimer’s disea se (AD) is a debilitating illness with unmet medical needs. The num ber of peopl e afflicted with the di sease worldwide is ex pected to triple by the year ۲۰۵۰. The multifactorial path ogenesis of AD include s accumulation of aggr egates of ȕ- amyloid (Aȕ) and tau protein and l oss of cholinergic neur ons, with co nsequent d eficit of the neurotrans mitter acetylcholine (AC h) [۱]. In advancing AD, AChE levels in the brain are declining, but a progre ssive incre ase (up to ۹۰%) of butyrylcholinesterase (BCh E, EC. ۳.۱.۱.۸) is obse rved, which too is able, even if at lower rate, to hydrolyze A ch [۲].

کلیدواژه ها:

Alzheimer’s disea se ، Quinoliz idinyl derivatives ، Gen etic algorith m ، QSAR.