Human protamine ۱ gene structure and function affected by rs۳۵۵۷۶۹۲۸ mutation: a bioinformatics analysis

Human sperm contain most type ۱ and type ۲ protamines (PRM۱) and (PRM۲), protamines, which have about equal proportions in normal sperm. Protamines can infertile if they change structure or function. Nucleotide polymorphisms are one cause of changes in protamine structure and function. For protamine ۱ the genetic variation rs۳۵۵۷۶۹۲۸ is known. In. this study bioinformatics approach was used to investigate the effects of the rs۳۵۵۷۶۹۲۸ mutation on protamine ۱ structure and function. matics tools including RNAsnp, NetGene۲, in this study several bioinformatics tools were used to investigate how the polymorphism affects RNA structure and splicing. The tools used included RNAsnp, NetGene۲, and ASAP. To evaluate the effects of rs۳۵۵۷۶۹۲۸ on proteins, other tools such as SNAP and ExPASy were also used. The analyzes have also shown that this polymorphism has the primary, secondary and The results of this study have also shown that this polymorphism has primary, secondary, and the results of this study have also shown that this polymorphism has primary, secondary, and results of this study have also shown that protamine ۱ has the following functions: general functions. Infertile males may be affected by rs۳۵۵۷۶۹۲۸ as it has destructive effects on protamine RNA and protein structure.

کلیدواژه ها:

Protamine ، Sperm ، Genetic polymorphism ، rs۳۵۵۷۶۹۲۸ ، Bioinformatics