Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice

Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), includinganalgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study evaluated the antidepressant-likeeffects of the CC essential oil (EO) on the forced swim test (FST) and tail suspension test (TST) in male mice.Materials and Methods: The gas chromatography-mass spectrometry (GC-MS) apparatus was used for detecting the chemical compoundsof CC EO. In the present study, ۷۲ male NMRI mice were randomly allocated to ۱۲ groups (each containing ۶ animals) including controlor vehicle (۱۰ mL/kg, i.p.), fluoxetine (۲۰ mg/kg, i.p.), imipramine (۳۰ mg/kg, i.p), and the CC EO (۱۰۰, ۲۰۰, and ۳۰۰ mg/kg, i.p.).Then, several parameters were measured and recorded, including immobility time, swimming time, and climbing time in FST, along withimmobility time in TST, respectively.Results: Cuminaldehyde followed by cymene, γ-terpinene, phenylglycol, ۲-caren-۱۰-al, ۲-β-pinene, acoradiene, and cuminic acid werethe major components of the CC EO. Based on the results, all doses of the CC, fluoxetine, and imipramine reduced immobility time in bothFST (P < ۰.۰۰۱) and TST (P < ۰.۰۰۱). On the other hand, all doses of the CC and fluoxetine increased swimming time (P < ۰.۰۰۱) althoughclimbing time was only increased by ۲۰۰ and ۳۰۰ mg/kg of the EO (P < ۰.۰۱ and P < ۰.۰۰۱, respectively) and imipramine (P < ۰.۰۰۱).Conclusion: Based on the findings of the present study, the components of the CC induced antidepressant-like activity similar to that offluoxetine and imipramine in both tests. However, further studies are required to confirm the role of different active components and theexact mechanism of action.

کلیدواژه ها:

Cuminum cyminum ، Depression ، Animal models ، Monoaminergic system ، Mice