Investigation on polypeptide-nanocomposite interactions: a case study of Sm/Fe۲O۳ bio-nanocomposite and its plasma protein adsorption

Herein, Samarium doped maghemite bio-nanocomposite (Sm/Fe۲O۳-NC) were synthesized by wet technique. The as-synthesized NC was evaluated by using XRD, SEM, EDX, DLS and zeta potential techniques. we investigate on the formation of protein corona on the surface of Sm/Fe۲O۳ in biological systems. After optimizing the proper concentration of the NC its attraction efficacy was evaluated by MDA-MB ۲۳۱ and RAW۲۶۴.۷ cells and showed attraction efficacy up to ۸۰%.

کلیدواژه ها:

polypeptide-nanocomposite interactions ، Sm/Fe۲O۳ bio-nanocomposite ، protein complex ، corona-coated nanomaterials