Herbal extract loaded nanofibers as a potential wound-dressing based on polycaprolactone (PCL)/chitosan (CN)/ Melilotus officinalis (MO)

Melilotus Officinalis (MO) is a herbal extract that can be added to wound dressing systems as a drug. It is taken into consideration to treat acute and chronic ulcers, especially burn wounds and diabetic lesions. This drug has been found to have strong antioxidant components such as ۷-hydroxycoumarin, flavonoids, and oleanane glucuronide. Due to these components, MO can be beneficial in reducing inflammation, regulating the immune system and improvement in vascularization. On the other hand, Electrospun nanofibers have many characteristics such as mimicking extracellular matrix structure, efficiency as bacterial barrier, appropriate water vapor transmission rate, and provision of adequate gaseous exchange which make them ideal candidates for wound-healing application. The aim of this study was to incorporate MO in electrospun nanofibers to benefit both the advantages of MO and electrospun nanofibers for the treatment of wounds. To this aim, the blend solution of polycaprolactone (PCL), chitosan (CN) and the herbal extract were electrospun and nanofibers loaded with the herbal extract were fabricated. Eventually, the optimized PCL/CN and PCL/CN/MO specimens were evaluated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Tensile, water contact angle, antibacterial assays, cell viability, and drug release analysis for determining their function and properties.

کلیدواژه ها:

Polycaprolactone (PCL) ، Chitosan (CN) ، Melilotus Officinalis extract (MO) ، Electrospinning ، Wound dressing.