Evaluation of the leaves extract of Rhazya stricta as An antifungal agent by GC-Mass analysis

Rhazya stricta (R. Stricta) Decne is one of the famous herbal plants that grow in the most desert areas in Iran, India, various regions of Pakistan and Western Asia. It has always played a major role in the treatment of human and animal diseases as a main role in the folk medicine. A large number of terpenoid indole alkaloids (TIAs) such as Eburenine and vincanine from transformed hairy root cultures of R. stricta were reported from crude extracts. Antibacterial activity of the non-alkaloid extract from R. stricta is likely to be related to the various phyto compounds, including flavonoids, terpenoids and tannins that were considered previously. The secondary metabolites such as flavonoids, phenolic and alkaloids (especially indole) compounds have been reported to have anticancerous properties. Antibacterial and antifungal activities of the fatty acids compounds have been already confirmed, too. The aim of this study was to explore the bioactive compounds in hydro alcoholic leaves extract of R. stricta by GC-Mass analysis. According to this research, some new alkaloids (like indole derivatives, Quebrachamine, Aspidospermidine, Vincadine, Akuammilan, Quebrachamine, Eburnamenine), several fatty acids and its derivatives, Quinoline and some natural antibiotic were detected.

کلیدواژه ها:

Rhazya stricta ، Hydro alcoholic Extraction ، Alkaloid ، Fatty Acid ، Antifungal