Investigating the effects of curcumin on cancers

Diet is one of the most important factors in preventing cancer. Many people around the world use a variety of ingredients in their diet, including spices such as red pepper, cloves, black pepper and cumin. Interestingly, these compounds are used as chemotherapeutic agents. One of the compounds considered for cancer treatment today is curcumin. Curcormin, which has been used in the treatment of many cancers, including cancers of the brain, breast, liver, leukemia, prostate, colon, etc. Curcumin, a natural flavonoid and proapoptotic combination of rhizome from Curcuma longa, has strong anti-inflammatory, antioxidant and In leukemia, this compound affects the modulation of NF-kappaB, Jak / STAT, WT۱, regulated extracellular signal kinase and other key molecules associated with tumorigenesis. Numerous dietary and pharmacological factors have been suggested as alternative strategies for the treatment and prevention of colorectal cancer. Curcumin, an active ingredient in turmeric, which inhibits the growth of malignant neoplasms, plays an important role in the prevention and treatment of colorectal cancer. EGF-R-associated protein (ERRP), a new inhibitor called erbB, is a potential therapeutic agent for colorectal cancer. Studies have shown the effect of curcumine on liver cancer cells. According to these studies, curcumin in different stages and fields such as: Regulation of several signal transduction pathways such as epidermal factor receptor, nuclear receptor, active protein ۱, hecting / TCF, activated motioganase protein kinase (MAPK) and Akt pathway, expression of many liver enzymes (such as c-jun, c-fos, c -myc, cyclooxygenase-۲ and NOS), which are involved in proliferation, differentiation, apoptosis and angiogenesis; Transcription factor Nuclear factor E۲ Factor ۲ (Nrf۲) involved in the regulation of the antioxidant response element (ARE) may play a role. According to our research, curcumin can play an important role in the treatment and prevention of many cancers

کلیدواژه ها:

curcumin ، cancer ، signal pathway