Eugenol effects on metabolic syndrome induced liver damages

Metabolic syndrome (MetS) is a set of risk factors associated with cardiovascular diseases, atherosclerosis, and type ۲ diabetes. Nonalcoholic fatty liver disease (NAFLD) is the most important liver disorder in metabolic syndrome. High fructose consumption increases the risk of NAFLD. Eugenol shows anti-thrombotic, insulin-sensitive, fat-reducing effects. This study was designed to investigate the protective role of eugenol in NAFLD caused by metabolic syndrome.. Methods Thirty male wistar rats were randomly divided to five groups. Group ۱, drinking water intake animals; group ۲, fructose, group ۳, fructose+eugenol solvent; group ۴, fructose+ eugenol ۵۰mg/kg and group ۵, fructose+ eugenol ۱۰۰mg/kg. At the end of experiment, after ۱۲ hours fasting and under anesthesia blood samples were taken for measurement of Fast Blood Glucose (FBS), SGOT, AGPT, LDL, HDL, cholesterol, triglyceride. Results FBG significantly increased in group ۲ compared to group ۱ (p<۰.۰۰۱), however, it significantly decreased in groups۴ and ۵ compared to group ۲ (p<۰.۰۵). SGOT and SGPT levels significantly increased in group ۲ compared to drinking water alone (p<۰.۰۰۱). However, SGOT and SGPT levels significantly decreased in groups ۴ and ۵. MDA and LTDS significantly increased in group ۲ compared with drinking water alone (p<۰.۰۱), while MDA and LTDS, decreased in ۴ and ۵ groups compared to group ۲ (p<۰.۰۵), which confirms the pathology results related to the liver damage. Conclusion Eugenol has protective effects on the liver and fat accumulation in liver cells.

کلیدواژه ها:

Eugenol ، fructose ، Metabolic syndrome ، Nonalcoholic fatty liver disease