Effects of curcumin on sleep quality and pattern in women with premenstrual syndrome and dysmenorrhea: a triple-blind, placebo-controlled clinical trial

Dysmenorrhea and excessive pain caused by premenstrual syndrome (PMS) can disturb sleep, reduce sleep quality and change sleep patterns. This triple-blind, placebo-controlled clinical trial assessed the effects of curcumin, a natural polyphenolic compound, on sleep pattern and quality in women with PMS and dysmenorrhea.Method: A sample of ۱۲۴ patients were included and randomly allocated into curcumin (n=۶۲)and control (n=۶۲) groups. Each subject received one capsules (۵۰۰ mg of curcuminoid, or placebo) daily, from ۷ days before until ۳ days after menstruation for three consecutive menstrual cycles. Insomnia and sleepiness were assessed using the Insomnia Severity Index (ISI) and Epworth sleepiness Scale (ESS) respectively, at the beginning and the end of the trial.Result: Baseline characteristics of individuals were comparable between the two groups. At the end of trial, there was a non-significant reduction was in insomnia and sleepiness scores in both curcumin and placebo groups (P>۰.۰۵). Participants in the both groups had a significant increase in nocturnal sleep duration (P<۰.۰۵). Whilst, the percentage of subjects showing improvement in insomnia status, daytime sleepiness severity, short sleep duration and difficult sleep initiation was not statistically significant between the curcumin and placebo groups (P>۰.۰۵).Conclusion: This study demonstrated that curcumin does not significantly affect sleep quality or pattern in young women with PMS and dysmenorrhea.

کلیدواژه ها:

Insomnia ، sleepiness ، dysmenorrhea ، Turmeric ، menstruation