Evaluation of the Relationship Between Serum levels of Zinc, Vitamin B۱۲, Vitamin D and Clinical outcomes in Patients with COVID-۱۹

Background and aims: Due to the known anti-inflammatory and antiviral effects of zinc, ۲۵(OH)D, and vitamin B۱۲, in this study, we explored the association between serum levels of these micronutrients in COVID-۱۹ patients at the time of admission and clinical outcomes. Material and methods: This study carried out on ۲۹۳ patients with COVID-۱۹ who were hospitalized at Imam Hassan hospital (Bojnourd, Iran). We collected demographic data, clinical characteristics, values of serum biochemical parameters on the first days of admission, and clinical outcomes from electronic medical records. We also measured serum levels of zinc, ۲۵(OH)D, and vitamin B۱۲ within three days of admission.Results: Of ۲۹۳ hospitalized, the median age was ۵۳ years, and ۱۴۷ (۵۰.۱۷%) were female. Thirty-seven patients (۱۲.۶۲%) admitted to the ICU, and forty-two (۱۴.۳۲%) died. We found significant correlations between age and ICU admission, intubation, or death (P˂۰.۰۵). Our results also indicated that there are significant relationships between mortality with intubation (P˂۰.۰۱), ICU admission (P˂۰.۰۰۱), and comorbidities (P˂۰.۰۱). We observed that serum levels of zinc, vitamin B۱۲, and ۲۵(OH)D are lower in patients who died than those who admitted to ICU or non-ICU and survived; however, these differences were not statistically significant for vitamin B۱۲ and ۲۵(OH)D (P˃۰.۰۵). The serum concentrations of zinc, vitamin B۱۲, and ۲۵(OH)D at the time of admission did not affect the length of hospital stay in COVID-۱۹ patients.Conclusion: In general, it seems that serum levels of ۲۵(OH)D, vitamin B۱۲, and especially zinc at the time of admission can affect clinical outcomes in COVID-۱۹ patients.

کلیدواژه ها:

COVID-۱۹ ، Vitamin B۱۲ ، Zinc ۲۵(OH)D ، Clinical outcome