Saffron Supplementation Effects on Inflammatory Indices and Hematological Factors in Type ۲ Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Background: Type ۲ diabetes (T۲D) is accompanied by elevated inflammation, oxidative stress, hyperlipidemia and hyperglycemia which all contribute to cardiovascular disease pathogenesis. Saffron as a complementary medicine and source of antioxidants could play a role in alleviating diabetes and its complications. The aim of this study was to determine the effects of saffron supplementation as an adjunct therapy in T۲D. Patients and Methods: This randomized controlled trial included ۸۰ T۲D patients with a mean age of ۵۴.۱ years. Participants were randomly assigned into two groups to take either saffron tablets (۱۰۰ mg/day; n=۴۰) or placebo (n=۴۰) for ۱۲ weeks. Fasting blood samples were obtained at the beginning and after the intervention period to quantify glycemic factors, lipid profile and biomarkers of inflammation and oxidative stress. Anthropometric indices and dietary intakes were also measured at baseline and at study end. Results: Compared with placebo, saffron supplementation resulted in significant decreases in waist circumference (p<۰.۰۰۱) and malondialdehyde (p=۰.۰۰۱). There was no statistically significant difference in other indices including anthropometric parameters, serum insulin, fasting blood glucose, HbA۱c, insulin sensitivity indices, lipid profile, high sensitivity C-reactive protein, total antioxidant capacity and tumor necrosis factor-α between the study groups (P > ۰.۰۵). Conclusions: Overall, ۱۲ weeks of saffron supplementation in diabetic patients had beneficial effects on waist circumference and serum malondialdehyde levels. However, saffron did not influence other evaluated cardio metabolic risk markers in diabetic patients.

کلیدواژه ها:

Crocus Sativus ، Diabetes Mellitus ، Type ۲ ، Dysglycemia ، Lipid profile ، Inflammation Mediators