Polymorphism of the cytochrome P-۴۵۰ ۱A۱ (A۲۴۵۵G) in women with breast cancer in Eastern Azerbaijan, Iran

Objective(s):Cytochrome P-۴۵۰ ۱A۱ is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. The present study evaluates the existence of CYP۱A۱ polymorphism in a number of breast cancer samples. Materials and Methods: One hundred breast cancer patients and the same number of healthy controls were analyzed for the A۲۴۵۵G polymorphism of cytochrome P-۴۵۰ ۱A۱ by the polymerase chain reaction-restriction fragment length polymorphism technique. Results: Frequency of heterozygote genotype (A/G) indicated significant increase in case group (۱۷%) compared to control group (۷%) (OR=۲.۷; ۹۵% CI=۱.۰۷-۶.۸۹; P-value=۰.۰۳). The related result of (A/A) genotype showed significantly decreased risk of breast cancer (OR=۰.۳۴;                  P-value=۰.۰۱). Higher frequency of heterozygotes was mainly observed among premenopausal breast cancer patients. Conclusion: Our results suggest that the CYP۱A۱polymorphism may be useful for predicting breast cancer risk in our study population.

کلیدواژه ها:

Breast Cancer ، CYP۱A۱ ، Polymorphism