Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B۱

سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 161

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شناسه ملی سند علمی:

JR_IJBMS-18-1_002

تاریخ نمایه سازی: 4 آبان 1400

چکیده مقاله:

Objective(s):Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B۱ (FB۱).    Materials and Methods: Twenty-nine female mice divided into treatment (n=۱۵) and control (n=۱۴) groups. The treatment group received FB۱ (۱۵۰ mg/kg diet) for ۱۶ weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa. Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P<۰.۰۵). Number of parietal cells significantly decreased in the treatment group in comparison with the control (P<۰.۰۵). Treatment with FB۱ for ۱۶ weeks significantly reduced both gastric mucosa height and mitotic index in the gastric glands (P<۰.۰۵). TUNEL- and Bax-labeled positive cell numbers significantly increased in the FB۱-treated group compared to the control (P<۰.۰۵). In addition, proliferative activity of gastric glands in the treated group was significantly lower than the control (P<۰.۰۵). Conclusion: Oral administration of FB۱ caused atrophy in gastric mucosa both via increasing of apoptosis and suppressing the mitotic activity of these cells.

نویسندگان

Ali Mohammad Alizadeh

۱ Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran ۲ Cancer Model Research Center, Tehran University of Medical Sciences, Tehran, Iran

Fahimeh Mohammadghasemi

Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Kazem Zendehdel

Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran

Zahra Kamyabi-moghaddam

Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

Abbas Tavassoli

Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

Fatemeh Amini najafi

Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

Alireza Khosravi

Medical Parasitology and Mycology Department, School of Medicine, Tehran University, Tehran, Iran

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