Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 19، شماره: 4
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 278
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شناسه ملی سند علمی:
JR_IJBMS-19-4_004
تاریخ نمایه سازی: 30 مهر 1400
چکیده مقاله:
Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts. Materials and methods:In this study ۱۰۵ Iranian infants with non-syndromic cleft lip/palate and ۲۱۸ controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and oral clefts. Maternal and parental smoking histories during pregnancy were obtained through questionnaire. DNA was extracted from newborn screening blood samples, and genotyping of the BamHI polymorphism in the TGFA gene was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. A number of factors including gender of the newborns, type of oral cleft, consanguinity of the parents, as well as the mother’s age and education were evaluated as potential confounders and effect modifiers. Results: Maternal smoking, in the absence of paternal smoking, was associated with an increased risk for CL/P (OR = ۱۹.۲, ۹۵% CI = [(۶.۲-۵۹.۵)]) and cleft palate only (OR =۴۸.۷, ۹۵% CI = [(۸-۲۹.۳)]). If both parents smoked, risks were generally greater (OR = ۵۵.۶, ۹۵% CI = [۱۲-۲۰.۲۵]). Analyses for the risk of clefting from maternal smoking, stratified by the presence or absence of the TGFA/BamH۱variant, revealed that the risk of clefting among the infants with the TGFA/BamH۱ variant when their mothers smoked cigarettes was much greater than the infants who had non-smoker mothers (P=۰.۰۰۱, OR=۱۰.۴,۹۵% CI=[۳.۲,۳۳.۶]). Conclusion:The results of this study indicate that first-trimester maternal smoking and infant TGFA locus mutations are both associated with nonsyndromic cleft lip and/or palate (CL/P).
کلیدواژه ها:
نویسندگان
Asghar Ebadifar
Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Roya Hamedi
Dental Carries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Hamid Reza KhorramKhorshid
Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Koorosh Kamali
Department of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran
Fatemeh Aghakhani Moghadam
Bachelors of Medical Laboratory Sciences, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
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