Animal models of Obsessive-Compulsive Disorder (OCD)

Treatment developments, brain imaging studies and results of pharmacological researches elicit re- vision of related pathological theories to Obsessive-compulsive disorder (OCD) and new research patterns. One of the important and alluring new research patterns under neurobiological approach corresponding to pathology and treatment of obsessive-compulsive disorder (OCD) are animal mod- els which are used in this disorder. Insomuch, many endeavors have been applied in order to expand animal models of OCD during recent ۳۰ years. In the hope of, increase our understanding and knowledge about pathology as well as treatment of this disorder. By considering the methodology of developing obsessive behaviors in animals, OCD animal models are divided into three classifications of behavioral, pharmacological and genetic. Researches and studies by using different animal models indicate the role of serotonin neurotransmitter particularly ۵-HT۲c receptor, Dopamine neurotrans- mitter particularly D۱ and D۲ receptors and at the less level the role of NMDA receptor of Glutamate neurotransmitter in pathology of OCD disorder.

کلیدواژه ها:

obsessive-compulsive disorder ، Animal models ، Behavioral models ، Pharmacological models ، Genetic models