Meconium microbial toxins and microbiota; a novel and non-invasive proposed diagnostic sample to anticipate severity of neonates COVID-۱۹

Background and Aim : After entrance of COVID-۱۹ into the body it could affect the balance of microbiota combination which can result in microbiota dysbiosis and eventually leads to immune imbalance. It is possible to observe simultaneous penetration of microbial toxic metabolites like bacterial lipopolysaccharide (LPS), into intrauterine space. This potent cytokine storm inducer then might lead to immune imbalances in neonates, which are predictable. It is demonstrated that COVID-۱۹ Spike protein attaches to bacterial LPS and increases inflammatory activations. N proteins of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) exasperate LPS causing pneumonia through triggering MASP-۲ activity. The presence and transmission of LPS to the fetus and pregnancy fluids and their potency to induce lung inflammatory diseases has also been demonstrated in previous studies. Based on these findings, we consider that it may be possible to measure the amount of LPS in the body as a prognostic marker of COVID-۱۹ in pregnant mother or newborn baby. Methods : narrative review Results : narrative review Conclusion : there has been no study conducted to test physiological relation of maternal microbiota toxic metabolites like bacterial LPS in COVID-۱۹ positive mothers and neonate’s meconium. We suggest to analyze meconium’s LPS levels and Gram-negative microbiota and detection of Corona virus itself as a noninvasive, reliable and potential test beside other virus detection methods of COVID-۱۹ in infants with COVID-۱۹ positive mothers. It could equip us with better strategies to keep newborns safe. Because levels of mentioned microbiome and their products like LPS, might act as a clock bomb during probable cytokine storm formation.

کلیدواژه ها:

Meconium ، LPS ، COVID۱۹ ، SARS-CoV-۲ ، Microbiota