The effect of probiotics on immune system function: Focus on studies in Iran

Background and Aim : Probiotics are living microorganisms with many benefits for the health if consumed in sufficient and appropriate amounts; One of the main and important mechanisms of action of these bacteria is host immune system regulation. In this article, the effects of probiotics on immune system functions would be presented with focus on studies have been conducted in IRAN.Methods : The search in reputable scientific sites and journals with suitable key words.Results : There are many findings with relatively extensive diversity about the effects of probiotics on immune system functions, but could be summarizes as the following: ۱. Extensive effects of probiotics on different parts of immune system: The functional ability of probiotics on immune system include: initiation of mucosal / systemic immune responses, modulation of the innate / adaptive immune system, stimulation of cytokine secretion etc. ۲. Probiotics can increase protection against the pathogens and improve the effectiveness of the vaccine. ۳.Beneficial effects of probiotics on some important disorders such as cancer, allergy and autoimmune diseases via modulation of immune functions. Studies have confirmed the effect of probiotics in the potential prevention of cancer or as adjunctive therapy during chemotherapy. In addition, probiotics improve allergy symptoms by modulating the Th۱ / Th۲ balance. ۴.There are some publications about molecular mechanisms for elucidation of probiotic effects. A review of recent studies in Iran and other studies suggests that probiotics may reduce NF-κβ activation and the production of proinflammatory cytokines. Probiotics have also been shown to increase intestinal barrier function by stimulating B cells and stimulating the production of immunoglobulin A. Some species of probiotic bacteria, such as Lactobacillus, play an important role in innate immunity by increasing the activity of natural killer cells and macrophages, and by interacting with dendritic cells and enterocytes. ۵.The effects of probiotics on immune system are partially species-specific and dose-dependent.Conclusion : The beneficial effects of probiotics on immune system functions have been verified, but more studies are needed to get the optimal use of probiotics.

کلیدواژه ها:

Probiotics ، Microbiota ، Allergy ، cancer ، immunomodulation