Bio-inspired silver selenide nano-chalcogens using aqueous extract of Melilotus officinalis with biological activities

Background and Aim : For the first time, an aqueous extract of Melilotus officinalis was used to synthesize bimetallic silver selenide chalcogenide nanostructures (Ag۲Se-NCs).Methods : he formation of NCs was confirmed and characterized by UV–visible and FTIR spectroscopy, SEM and TEM imaging, XRD and EDX crystallography, zeta potential (ZP) and size distribution (DLS). The bioactivities of biosynthesized Ag۲Se-NCs, such as antibacterial, antibiofilm, antioxidant and cytotoxicity potentials, were then examined.Results : Bio-based Ag۲Se-NCs were successfully synthesized with mostly spherical shape in the size range of ۲۰–۴۰ nm. Additionally, the MIC and MBC values of Ag۲Se-NCs against β-lactam-resistant Pseudomonas aeruginosa (ATCC ۲۷۸۵۳) were ۳.۱۲ and ۵۰ µg/ml, respectively. The DPPH scavenging potential of Ag۲Se-NCs in terms of IC۵۰ was estimated to be ۵۸.۵۲. Green-synthesized Ag۲Se-NCs have been shown to have promising benefits and could be used for biomedical applications Conclusion : lthough the findings indicate promising bioactivity of Ag۲Se-NCs synthesized by M. officinalis extract (MO), more studies are required to clarify the comprehensive mechanistic biological activities.

کلیدواژه ها:

Silver selenide nano-chalcogens (Ag۲Se-NCs) ، Melilotus officinalis ، Pseudomonas aeruginosa ، Biological activities