The Effects of Hydroalcoholic Extract of Artemisia absinthium L on Blood Glucose in Diabetic Rats

Nearly ۵ million people in Iran have diabetes and this number reaches ۴۰۰ million worldwide. Researchers are looking for drugs with less side effects to control diabetes. Artemisia absinthium L has many medicinal uses and is found in most cities of Iran. In this study, we investigated the effect of its hydroalcoholic extract on diabetic rats. In this Research ۴۰ male Wistar rats (۲۰۰-۲۵۰ g) randomly divided into ۵ equal groups. Normal Control, the control group received the hydroalcoholic extract of Artemisia absinthium, control diabetic and Two treatment diabetic groups received ۸۰ and ۱۲۰ mg/Kg of hydroalcoholic extract of Artemisia absinthium, respectively. to induce diabetes in the control diabetic and Diabetic Treated, streptozotocin (۶۰ mg / kg) was injected intraperitoneally. All rats were treated orally by gavage which continued daily for ۳ weeks. Finally, was measured the level of glucose of the animal s serum. Blood glucose levels were significantly lower in the extract-treated groups than in the diabetic control group. The decreasing effects increased with increasing of the amount of extract. Animal weight was also increased in all groups treated with the extract. .The extract of Artemisia absinthium, due to the presence of flavonoid compounds and polyphenols, has a lowering effect on blood glucose.

کلیدواژه ها:

Diabetes ، Streptozotocin ، Medicinal plant