Evaluation of the Nanoparticles Containing Tyrosol Effect on the Expression of GLUT۲ and GLUT۹ Genes in Diabetic Rats

Diabetes, a metabolic disease with decreased insulin secretion or insulin insufficiency and high blood sugar, has three different types, and about ۹۰ percent of type ۲ diabetes. Given the destruction of the International Diabetes Association (IDF), which will increase the number of patients to ۵۹۲ million by ۲۰۲۵, it is crucial to address the challenge of treating type ۲ diabetes (۱, ۲, ۳). High blood sugar is one of the aggravating factors of this disease, and so far, the conventional treatment strategies have not been effective in transferring glucose into the cell. GLUT۲ and GLUT۹ are facilitated membrane glucose transporter that facilitates blood glucose release through the kidney, liver, and placenta's plasma membrane. In addition to its anti-inflammatory and antioxidant properties, tyrosol has been shown to have insulin-like functional properties that face the challenge of targeted cell delivery. Niosome carriers; or nonionic surfactant vesicles can be valuable in the targeted delivery of tyrosol to the cell . In this study, Niosome carriers' function in targeted tyrosol transfer to rat hepatocytes was evaluated by measuring the expression of GLUT۲ and GLUT۹ genes. For this purpose, diabetic rats were divided into five groups: control, diabetic, nanoniosome, tyrosol and nanotyrosol and were treated for ۴۵ days. After dissection and extraction of liver tissue, the expression of GLUT۲ and GLUT۹ genes was measured by real-time PCR. The nanotyrosol and tyrosol groups showed the highest gene expression, respectively.

کلیدواژه ها:

Type ۲ diabetes ، Thyrozol ، Niosome ، GLUT۲ ، GLUT۹