Non-steroidal Anti-inflammatory Drug, Tolmetin Attenuates Pentylenetetrazole-induced Seizure and Improve Passive Avoidance Memory Deficits in Male Wistar Rats

Large body of evidence suggests that anti-inflammatory agents and antioxidants have neuroprotective properties and may be beneficial in the treatment of neurodegenerative disorders. To evaluate the effect of tolmetin (a non-steroidal anti-inflammatory drug) on experimental models of seizures, and seizure-induced memory impairment in rats. In this experimental study, male Wistar rats (۲۰۰-۲۲۰ g) randomly divided to negative control (saline injection), positive control (pentylenetetrazole (PTZ) injection) and the tolmetin (۵۰, and ۱۰۰, mg/kg ,intraperitoneally). Seizures were induced in by PTZ (۶۰ mg/kg) and the anticonvulsant effect of the tolmetin was evaluated in seizure models. Effect on memory was assessed using passive avoidance test (PA). In experimental study, PTZ treated groups exhibited seizures with cognitive deficits (p < ۰.۰۱) as compared to control group. Tolmetin at highest dose (۱۰۰ mg/kg) showed protection in PTZ induced seizures. In addition, it also attenuated the seizure induced memory impairment as indicated by significant (p < ۰.۰۵) improvement in the retention latencies in PA as compared to PTZ treated group .The findings suggest that tolmetin exhibited significant anticonvulsant activity and indicate its usefulness as an adjuvant to antiepileptic drugs with an advantage of preventing memory impairment.

کلیدواژه ها:

Anticonvulsant ، Behavioral test ، Drug pharmacology ، Neurodegenerative disorders