Molecular Biophysics of SARS-CoV-۲ virus and its susesepibiliy
سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 97
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
BIOCONF21_0520
تاریخ نمایه سازی: 7 شهریور 1400
چکیده مقاله:
SARS-CoV-۲ corona virus that caused the Covid-۱۹ Pandemic, is composed of the lipid bilayer membrane and several constituent antigenic proteins including; Spike, Orf۳a, and other envelope (E) proteins that can be used as potential targets for treating the virus in a non-clinical and genetically manner. The known atomic structure of the mentioned molecules at atomic level has made it possible to take biophysical approaches focusing on the charges, intra and intermolecular electrostatic interaction and forces, as well as their physico-chemical interactions with the medium co-ions and counter-ions, pH, temperature and water status as the neutralizing, destructing and treating agents. Furthermore, due to the atomic and molecular characteristics and configuration of virus, it can be considered likewise solid state materials and expect to affect its electrical status by exposing it to external electrical, magnetic and elecromagnetic fields for the detection and inactivation purposes. The conformation of the spike protein and its functional antigenic status is achieved and stabilized by intramolecular and inter-molecular forces that are susceptible to the external fields. Here, the ultrastructure of the virus will be discussed and different approaches considered to study and treat its membrane and constituent proteins for detection and inactivation purposes are presented. Our voltage clamp experiments have shown EMF effect on the lipid membrane integrity and voltage-dependent channel activities leading to pore formation and ultimate destruction of the membrane. Furthermore, the applied EMF caused decreased voltage sensitivity and long lasting inactivation of the voltage dependent OmpF voltage gated channel. Accordingly, although, the actual contribution of the voltage-gated rectifier OrfA channel is not fully known yet, we expect that exposing it to the external EMF can interfere with its activity and possible deviation of the virus functionality and ingrity and corresponding response be used for detection purposes.
کلیدواژه ها:
نویسندگان
Hamid Mobasheri-
Professor of Biophysics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran